Article
MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.
Scientific reports - 14 Dec 2015
Chiavacci Elena, D'Aurizio Romina, Guzzolino Elena, Russo Francesco, Baumgart Mario, Groth Marco, Mariani Laura, D'Onofrio Mara, Arisi Ivan, Pellegrini Marco, Cellerino Alessandro, Cremisi Federico, Pitto Letizia
Abstract excerpt
Holt-Oram Syndrome (HOS) is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene, a transcription factor capable of regulating hundreds of cardiac-specific genes through complex transcriptional networks. Here we show that, in zebrafish, modulation of a single miRNA is sufficient to rescue the morphogenetic defects generated by HOS. The analysis of miRNA-seq profiling revealed a decreased...
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