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Wnt Signaling Inhibitors as Therapeutic Approach in Ischemic Heart Disease

17 Dec 2024

Abstract excerpt

Wnt (wingless-type MMTV integration site family) signaling is an evolutionary conserved system highly active during embryogenesis, but in adult hearts has low activities under normal conditions. It is essential for a variety of physiological processes including stem cell regeneration, proliferation, migration, cell polarity, and morphogenesis, thereby ensuring homeostasis and regeneration of cardiac tissue. Its...

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PMID: 39770047
DOI: 10.3390/molecules29245958

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