Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PD-L1 and MRN synergy in platinum-based chemoresistance of head and neck squamous cell carcinoma

19 Dec 2019

Abstract excerpt

BACKGROUND: We have been investigating the molecular mechanisms of cisplatin-induced chemoresistance in head and neck squamous cell carcinoma (HNSCC). Based on our previous findings, the present study investigates how the Mre11, Rad50, and NBS1 (MRN) DNA repair complex interacts at the molecular level with the programmed cell death ligand 1 (PD-L1) in cisplatin-induced chemoresistance. METHODS: Human HNSCC cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31853007
DOI: 10.1038/s41416-019-0697-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PD-L1 and MRN synergy in platinum-based chemoresistance of head and neck squamous cell carcinomaPMID 31853007Read ↗

Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapySemantic proximity Read ↗

Cisplatin-induced genetic alterations in KEAP1 promote therapeutic resistance in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathwaySemantic proximity Read ↗

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.Semantic proximity Read ↗

Mutant Nbs1 enhances cisplatin-induced DNA damage and cytotoxicity in head and neck cancer.Semantic proximity Read ↗

Epithelial–mesenchymal transition and cancer stem cells: A route to acquired cisplatin resistance through epigenetics in HNSCCSemantic proximity Read ↗

Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targetingSemantic proximity Read ↗

Identification of miRNAs contributing to neuroblastoma chemoresistanceSemantic proximity Read ↗

Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.