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Article

Comprehensive genomic and transcriptomic characterization of high-grade gastro-entero-pancreatic neoplasms.

British journal of cancer - 1 Jul 2024

Angerilli Valentina, Sabella Giovanna, Simbolo Michele, Lagano Vincenzo, Centonze Giovanni, Gentili Marco, Mangogna Alessandro, Coppa Jorgelina, Munari Giada, Businello Gianluca, Borga Chiara, Schiavi Francesca, Pusceddu Sara, Leporati Rita, Oldani Simone, Fassan Matteo, Milione Massimo

Abstract excerpt

BACKGROUND: High-grade gastro-entero-pancreatic neoplasms (HG GEP-NENs) can be stratified according to their morphology and Ki-67 values into three prognostic classes: neuroendocrine tumors grade 3 (NETs G3), neuroendocrine carcinomas with Ki-67 < 55% (NECs <55) and NECs with Ki-67 ≥ 55% (NECs ≥55). METHODS: We analyzed a cohort of 49 HG GEP-NENs by targeted Next-Generation Sequencing (TrueSight Oncology 500),...

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Identifiers

PMID: 38729995
DOI: 10.1038/s41416-024-02705-8
PMCID: PMC11231306

Genes

APC
KRAS
MEN1
TP53
CD4

Provenance

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