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Causal Relationship Between Serum Zinc Levels and Diabetic Kidney Disease (DKD): A Plasma Proteomics Mediation Study.

Biological trace element research - 1 Mar 2026

Zhao Chunbo, Pan Tingting, Liu Wei, Cheng Fanqian, Zhao Xiaoxuan, Yu Shuxin, Yang Yi, Zhang Ran, Sun Weixia

Abstract excerpt

The association between serum zinc levels and diabetic kidney disease (DKD) has been a focus of considerable scientific interest. Lower serum zinc has been observed to be involved in the progression of DKD, and zinc supplementation can improve the kidney damage of DKD. However, the causal link and the underlying mechanisms driving this association remain poorly understood. A two-sample Mendelian randomization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40830297
DOI: 10.1007/s12011-025-04782-z
PMCID: PMC12992405

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