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Causal relationships between the gut microbiota, immune cells, and diabetic kidney disease: a Mendelian randomization and mediation analysis.

Renal failure - 1 Dec 2026

Yan Han, Pang Haipeng, Xie Lingxiang, Ding Jin, Peng Yiman, Yang Yuanqin, Zhou Zhiguang, Li Xi, Hu Jingyi

Abstract excerpt

Observational studies have indicated that the gut microbiota is associated with diabetic kidney disease (DKD). However, it remains unclear whether disturbances in the gut microbiota causally contribute to DKD. This study aimed to investigate the causal relationships between the gut microbiota and DKD and explore peripheral immune cell traits as potential mediators. Summary statistics were extracted from...

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Diabetes Mellitus, Type 2
Diabetic Nephropathies
Gastrointestinal Microbiome
Genome-Wide Association Study
Interleukin-2 Receptor alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mediation Analysis

Mendelian Randomization Analysis

T-Lymphocytes, Regulatory

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PMID: 42508992
DOI: 10.1080/0886022X.2026.2682003
PMCID: PMC13410746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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