Article
Global Pangenome Analysis Highlights the Critical Role of Structural Variants in Cattle Improvement and Identifies a Unique Event as a Novel Enhancer in IGFBP7+ Cells.
Molecular biology and evolution - 1 Sept 2025
Dai Shoulu, Zhao Pengju, Li Wenhao, Peng Lingwei, Jiang Enhui, Du Yuqin, Zhang Wengang, Dai Xuelei, Yang Liu, Li Zhiqiang, Xu Linjing, Lan Xianyong, Lyu Wenfa, Yang Liguo, Fang Lingzhao, Liu George E, Zhou Yang
Abstract excerpt
Based on a pangenome graph platform, we simultaneously analyzed the impacts of SNPs and SVs in the population structure and phenotypic formation of global cattle using 2,409 individuals from 82 breeds. We demonstrated that SVs, like SNPs, effectively explain the population structure of global cattle. Genomic regions under strong selection, identified using both SNPs and SVs, consistently revealed footprints...
Read the complete abstract on PubMedTopics
- Animals
- Cattle
- Polymorphism, Single Nucleotide
- Selection, Genetic
- Insulin-Like Growth Factor Binding Proteins