Article
Pangenome-genotyped structural variation improves molecular phenotype mapping in cattle.
Genome research - 20 Mar 2024
Leonard Alexander S, Mapel Xena M, Pausch Hubert
Abstract excerpt
Expression and splicing quantitative trait loci (e/sQTL) are large contributors to phenotypic variability. Achieving sufficient statistical power for e/sQTL mapping requires large cohorts with both genotypes and molecular phenotypes, and so, the genomic variation is often called from short-read alignments, which are unable to comprehensively resolve structural variation. Here we build a pangenome from 16 HiFi...
Topics
- Male
- Cattle
- Animals
- Genotype
- Quantitative Trait Loci
- Phenotype
- RNA Splicing
- Linkage Disequilibrium
- Genomic Structural Variation