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Article

Long read and preliminary pangenome analyses reveal breed-specific structural variations and novel sequences in Holstein and Jersey cattle.

Journal of advanced research - 1 Jan 2026

Gao Yahui, Yang Liu, Kuhn Kristen, Li Wenli, Zanton Geoffrey, Bowman Mary, Zhao Pengju, Zhou Yang, Fang Lingzhao, Cole John B, Rosen Benjamin D, Ma Li, Li Congjun, Baldwin Ransom L, Van Tassell Curtis P, Zhang Zhe, Smith Timothy P L, Liu George E

Abstract excerpt

INTRODUCTION: Most SV studies in livestock rely on short-read sequencing, posing challenges in accurately characterizing large genomic variants due to their limited read length. OBJECTIVES: Our goal is to reveal structural variation and novel sequences specific to Holstein and Jersey cattle breeds using long-read and pan-genome analyses. METHODS: We sequenced 20 Holsteins and 8 Jersey cattle using PacBio HiFi to...

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PMID: 40258473
DOI: 10.1016/j.jare.2025.04.014
PMCID: PMC12766236

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