Fission yeast Rad54 prevents intergenerational buildup of Rad51 aggregates in proliferating cells.

Abstract excerpt

Homologous recombination is central to the maintenance of genome stability. Using fission yeast, we found that mutation of the rad54 gene leads to robust Rad51 accumulation in vegetatively growing cells. By developing a protocol to track Rad51 in live yeast cells, we traced the origin and fate of Rad51 aggregates formed in rad54 mutants. Our observations strongly suggest that DNA breaks arising in late S phase...

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• DNA Breaks, Double-Stranded
• DNA Helicases
• Genomic Instability
• Homologous Recombination
• Rad51 Recombinase