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Mediators linking gut microbiota and sporadic Creutzfeldt–Jakob disease: a Mendelian randomization study

18 Aug 2025

Abstract excerpt

Abstract While gut microbiome associations with sporadic Creutzfeldt–Jakob disease (sCJD) are recognized, causal mechanisms and mediation via cerebrospinal fluid (CSF) metabolites remain unestablished. Using bidirectional Mendelian randomization (MR) with mediation analysis and integrating genome-wide association study (GWAS) summary statistics from gut microbiota (composition in the FINRISK 2002 prospective...

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PMID: 40824609
DOI: 10.1186/s13568-025-01932-3

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