Genetic prediction of blood metabolites mediating the relationship between gut microbiota and Alzheimer’s disease: a Mendelian randomization study

Abstract excerpt

Background Observational studies have suggested an association between gut microbiota and Alzheimer’s disease (AD); however, the causal relationship remains unclear, and the role of blood metabolites in this association remains elusive. Purpose To elucidate the causal relationship between gut microbiota and AD and to investigate whether blood metabolites serve as potential mediators. Materials and methods...

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