Assessment of Bidirectional Relationships Between 98 Genera of the Human Gut Microbiota and Amyotrophic Lateral Sclerosis: A 2-Sample Mendelian Randomization Study

Abstract excerpt

<title>Abstract</title> <p><bold><italic>Background</italic></bold>Growing evidence suggests a mutual interaction between gut microbiome alterations and ALS pathogenesis. However, previous studies were susceptible to potential confounding factors and reverse causation bias, likely leading to inconsistent and biased results. Therefore, to decipher the potentially mutual relationship between gut microbiota and ALS,...

Topics

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• Amyotrophic Lateral Sclerosis
• Causality
• Gastrointestinal Microbiome
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Parkinson Disease
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

09e16cef-532b-5bc4-8e73-6deaf4f8b466

DOI

10.21203/rs.3.rs-526836/v1