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Bidirectional Two-Sample, Two-Step Mendelian Randomisation Study Reveals Mediating Role of Gut Microbiota Between Vitamin B Supplementation and Alzheimer’s Disease

18 Nov 2024

Abstract excerpt

Objectives: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with a complex aetiology. The aims of this study were to investigate the relationship between vitamin B supplementation and AD risk and to explore the potential mediating effect of the gut microbiota in this relationship. Methods: We employed a Mendelian randomisation analysis to examine the association between different vitamin B...

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PMID: 39599715
DOI: 10.3390/nu16223929

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