Unraveling the connection between gut microbiota and Alzheimer’s disease: a two-sample Mendelian randomization analysis

Abstract excerpt

Purpose Studies have shown a close relationship between gut microbiota (GM) and Alzheimer’s disease (AD). However, the causal relationship between them remains unclear. Methods We conducted a genome-wide association study (GWAS) using publicly available summary statistics data for GM and AD. We extracted independent genetic loci significantly associated with GM relative abundances as instrumental variables based...

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