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Article

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for lung cancer.

BMC cancer - 4 Jun 2024

Song Wenfu, Li Yingying, Yao Yaxuan, Sun Shiling, Guan Xutao, Wang Bing

Abstract excerpt

BACKGROUND: Drug repurposing provides a cost-effective approach to address the need for lung cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR). METHODS: Summary-level data of gene expression quantitative trait loci (eQTLs) were sourced from the eQTLGen resource. We procured genetic associations with lung cancer and its subtypes from the TRICL,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38834983
DOI: 10.1186/s12885-024-12449-6
PMCID: PMC11151555

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