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Biophysical analysis of an oligomerization-attenuated variant of the Leishmania donovani dynamin-1-like protein.

Molecular and biochemical parasitology - 1 Sept 2025

Wuyts Ellen, Sundaramoorthy Ramasubramanian, Tulloch Lindsay, Monsieurs Pieter, Eadsforth Thomas C, Pintelon Isabel, Timmermans Jean-Pierre, Dujardin Jean-Claude, Domagalska Malgorzata Anna, Caljon Guy, De Rycker Manu, Postis Vincent L G, Wyllie Susan, Sterckx Yann G-J

Abstract excerpt

Chemotherapy is a cornerstone in the battle against leishmaniasis, a neglected tropical disease caused by Leishmania parasites that affects millions worldwide. An alarming number of reports are describing treatment failure with currently available drugs, thereby explaining the dire need for the discovery of novel compounds, preferably with yet unexplored modes of action. In this respect L. donovani dynamin-1 like...

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PMID: 40818547
DOI: 10.1016/j.molbiopara.2025.111691

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