Article
Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro.
PloS one - 1 Jan 2018
Lunev Sergey, Butzloff Sabine, Romero Atilio R, Linzke Marleen, Batista Fernando A, Meissner Kamila A, Müller Ingrid B, Adawy Alaa, Wrenger Carsten, Groves Matthew R
Abstract excerpt
Malaria remains a major threat to human health, as strains resistant to current therapeutics are discovered. Efforts in finding new drug targets are hampered by the lack of sufficiently specific tools to provide target validation prior to initiating expensive drug discovery projects. Thus, new approaches that can rapidly enable drug target validation are of significant interest. In this manuscript we present the...
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