Article
Biochemical characterization of human dynamin-like protein 1.
Journal of biochemistry - 1 Dec 2011
Zhang Yanfeng, Gao Xiaoli, Garavito R Michael
Abstract excerpt
Human dynamin-like protein 1 (DLP-1) is involved in the fission of mitochondrial outer membranes, a process that helps to maintain mitochondrial morphology and to reduce the accumulation of functional and structural defects in mitochondria. DLP-1 is a ~80 kDa membrane-interacting protein and contains a GTPase domain, a middle domain, a putative PH-like domain and a GTPase effector domain (GED). While the GED has...
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