Article
Biochemical characterization of human dynamin-like protein 1.
Journal of biochemistry - 1 Dec 2011
Zhang Yanfeng, Gao Xiaoli, Garavito R Michael
Abstract excerpt
Human dynamin-like protein 1 (DLP-1) is involved in the fission of mitochondrial outer membranes, a process that helps to maintain mitochondrial morphology and to reduce the accumulation of functional and structural defects in mitochondria. DLP-1 is a ~80 kDa membrane-interacting protein and contains a GTPase domain, a middle domain, a putative PH-like domain and a GTPase effector domain (GED). While the GED has...
Topics
- Amino Acid Sequence
- Chromatography, Gel
- Cloning, Molecular
- Dynamins
- Enzyme Activation
- Escherichia coli
- GTP Phosphohydrolases
- Humans
- Liposomes
- Microtubule-Associated Proteins
- Mitochondria
- Mitochondrial Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Interaction Domains and Motifs
- Protein Interaction Mapping
- Protein Isoforms