Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low frequency variants can predetermine antiviral drug resistance development in herpes simplex virus type 1.

PLoS pathogens - 1 Jun 2026

Jaki Lena, Full Florian, Gieraths Udo, Falcone Valeria, Ruzsics Zsolt, Hengel Hartmut, Panning Marcus, Fuchs Jonas

Abstract excerpt

Severe HSV-1 disease is treated with potent antiviral drugs, in particular aciclovir (ACV) and its derivatives. However, long-term drug exposure in immunocompromised patients can lead to the emergence of ACV-resistant HSV-1 strains and clinical treatment failure. To understand how phenotypic resistances develop on a genomic level, we analyzed the influence of ACV selection pressure on the viral genome of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyclovir
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Genome, Viral

Share to Herpes Simplex

Share to Herpesvirus 1, Human

Share to Vero Cells

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 42258558
DOI: 10.1371/journal.ppat.1014296
PMCID: PMC13262928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low frequency variants can predetermine antiviral drug resistance development in herpes simplex virus type 1.PMID 42258558Read ↗

High prevalence but low clinical impact of acyclovir-resistant herpes simplex virus type 1 infections in patients with hematologic disorders.Semantic proximity Read ↗

Six years of clinical herpes simplex virus genotypic acyclovir resistance testing confirms common resistance mechanisms and identifies novel mutationsSemantic proximity Read ↗

Clinical and genotypic characteristics of antiviral-resistant herpes simplex virus 1 and 2 infections: a case series.Semantic proximity Read ↗

Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations.Semantic proximity Read ↗

Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals.Semantic proximity Read ↗

Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.Semantic proximity Read ↗

Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1.Semantic proximity Read ↗

Surveillance of herpes simplex virus resistance to antivirals: a 4-year survey.Semantic proximity Read ↗

Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.Semantic proximity Read ↗

<i>In vitro</i> evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in Vero cell cultureSemantic proximity Read ↗

A Mutation in the Herpes Simplex Virus Type 1 (HSV-1) UL29 Gene is Associated with Anti-Herpesvirus Drugs' Susceptibility.Semantic proximity Read ↗

Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.