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Article

Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids

15 Aug 2025

Abstract excerpt

The developmental origin of Alzheimer disease (AD) has been proposed but is arguably debated. Here, we developed cerebral organoids from induced pluripotent stem cells (iPSCs) with mutations in amyloid precursor protein (APP) associated with familial AD (fAD) and analyzed the dynamic changes of cellular states. We found that mature neurons induced in fAD organoids markedly decreased compared to that of health...

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PMID: 40816274
DOI: 10.1016/j.stemcr.2025.102601

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