MicroRNAs: Game Changers in the Regulation ofα-Synuclein in Parkinson’s Disease

Abstract excerpt

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Its neuropathological hallmarks include neuronal loss in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies containing aggregates ofα-synuclein (α-syn). An imbalance between the rates ofα-syn synthesis, aggregation, and clearance can result in abnormalα-syn levels and contribute to the pathogenesis of PD....

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