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Article

Genetic and clinical factors associated with the metabolism of valproic acid in post-neurosurgery patients.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Aug 2025

Cai Xinfeng, Wen Hongping, Ma Jiuhong, Li Xingang, Cheng Gang, Tian Shuangshuang, Wu Xinjing, Hao Zhiying, Guo Jinlin

Abstract excerpt

Valproic acid (VPA) is commonly used to treat epilepsy and bipolar disorder, requiring therapeutic concentrations of 50-100 mg/L to balance efficacy and safety. Despite known clinical and genetic factors influencing VPA metabolism, integrated predictive models are limited. This study analyzed VPA concentrations in 497 samples from 275 Chinese participants, examining 23 clinical variables and 24 genetic SNPs....

Read the complete abstract on PubMed

Topics

Adolescent
Adult
Aged
Female
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Young Adult

Anticonvulsants

Bipolar Disorder

Cytochrome P-450 CYP2C19

Epilepsy

Neurosurgical Procedures

Polymorphism, Single Nucleotide

Valproic Acid

East Asian People

Source

Identifiers

PMID: 40812711
DOI: 10.1016/j.pnpbp.2025.111468

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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