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Article

Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype.

Scientific reports - 3 Aug 2021

Torres-Querol Coral, Torres Pascual, Vidal Noemí, Portero-Otín Manel, Arque Gloria, Purroy Francisco

Abstract excerpt

Senescent cells are capable of expressing a myriad of inflammatory cytokines and this pro-inflammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ischemia was scarce. A mouse model of transient focal cerebral ischemia by compressing the distal middle cerebral artery (tMCAo) for 60 min was used. SASP, pro-inflammatory cytokines and cell...

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Identifiers

PMID: 34344977
DOI: 10.1038/s41598-021-95344-5
PMCID: PMC8333348

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