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ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection

13 Aug 2025

Abstract excerpt

The ERK-mediated phosphorylation of the core m6A methyltransferase METTL3 has been linked to the regulation of embryonic stem cell differentiation and tumorigenesis. However, its role in the antiviral innate immune response remains unclear. In this study, we found that during infection with the prototypical alpha-herpesvirus Pseudorabies virus (PRV), ERK2 protein expression increased significantly, while METTL3...

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interferon and immune responses
Vector-Borne Animal Diseases
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40802811
DOI: 10.1371/journal.ppat.1013234

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