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Article

[Factors determining the instability of the conformation of human mutant hemoglobins. A method for evaluating the instability].

Molekuliarnaia biologiia - 1 Jan 2000

Shindialov I N, Kolchanov N A

Abstract excerpt

A method that allows to estimate the influence of single amino acid substitutions on the stability of proteins with known three-dimensional structure was developed. The role of 20 different physico-chemical properties of amino acids and some characteristics of the three-dimensional structure in the destabilization of protein structure caused by mutations was analyzed. Analysis of 54 proteins led us to reveal the...

Topics

Amino Acid Sequence
Chemical Phenomena
Chemistry, Physical
Hemoglobins, Abnormal
Humans
Models, Molecular
Mutation
Protein Conformation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 4079930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-4079930-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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