Article

Prediction of the stability of proteins by computational approaches: a case report

2018-11-05

Abstract excerpt

The prediction of the stability of a protein is a very important issue in computational biology. Indeed, missense mutations are frequently associated to a change in protein stability, leading usually to destabilization, unfolding and aggregation. However, the direct measurement of the effect of mutations on proteins' stability is often impaired by the large number of mutations that can affect a protein sequence. T...

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Literature Corpus work: 1bc4016f-a15c-5398-9124-b5e8af97ff3b
DOI: 10.7287/peerj.preprints.27319v1

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