Article
The unstable haemoglobins.
Blood reviews - 1 Sept 1993
Williamson D
Abstract excerpt
The unstable haemoglobin haemolytic anaemias result from the presence in the red cell of a structurally abnormal haemoglobin variant. There are many mutations producing unstable haemoglobins; most are single amino acid replacements that affect a few key areas of the haemoglobin structure. A wide range of haemoglobin instability is evident from in vitro studies, extending from mutants with a subclinical degree of...
Topics
- Amino Acid Sequence
- Anemia, Hemolytic
- Binding Sites
- Chemical Precipitation
- Endopeptidases
- Globins
- Hemoglobinopathies
- Hemoglobins, Abnormal
- Hemolysis
- Humans
- Methemoglobin
- Molecular Sequence Data