Article
The unstable haemoglobins.
Blood reviews - 1 Sept 1993
Williamson D
Abstract excerpt
The unstable haemoglobin haemolytic anaemias result from the presence in the red cell of a structurally abnormal haemoglobin variant. There are many mutations producing unstable haemoglobins; most are single amino acid replacements that affect a few key areas of the haemoglobin structure. A wide range of haemoglobin instability is evident from in vitro studies, extending from mutants with a subclinical degree of...
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