[Equilibrium unfolding of mutant apomyoglobins with substitutions of conserved nonfunctional residues by alanine].

Abstract excerpt

The problems of protein aggregation and protein misfolding in the cell are connected with the appearance of many genetic diseases. Both processes can be a consequence of substitutions of certain amino acid residues in proteins. The substitutions can influence the protein stability and protein folding rates in both the intermediate and the native states. We have studied equilibrium urea unfolding of mutant forms...

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