Article
Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006
Abouzahr Soraya, Bismuth Georges, Gaudin Catherine, Caroll Oliver, Van Endert Peter, Jalil Abdelali, Dausset Jean, Vergnon Isabelle, Richon Catherine, Kauffmann Audrey, Galon Jérôme, Raposo Graca, Mami-Chouaib Fathia, Chouaib Salem
Abstract excerpt
To investigate tumor resistance to T cell lysis, a resistant variant was selected after specific cytolytic T lymphocytes (CTL) selection pressure. Although the resistant variant triggered perforin and granzyme B transcription in specific CTLs, as well as their degranulation, it exhibited a dramatic resistance to cytotoxic T cell killing. It also displayed strong morphological changes with alterations of the actin...
Topics
- Actins
- Cell Line, Tumor
- Ephrin-A1
- Gelsolin
- Gene Silencing
- Genetic Variation
- Humans
- Immunoprecipitation
- Microscopy, Confocal