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Article

Rate of germline pathogenic sequence variants in cancer susceptibility genes in an Israeli pediatric and adolescent cancer cohort: a single institute experience.

Familial cancer - 8 Aug 2025

Nahom Dana, Frenkel Zehavit, Toren Amos, Friedman Eitan, Kventsel Iris

Abstract excerpt

Multi-cancer predisposition gene panel testing (MCPGT) enables simultaneous deep-coverage genotyping of multiple CPGs (cancer predisposing genes) and detects germline pathogenic sequence variants (PSVs). Reported PSV carrier rates among pediatric and adolescent cancer patients range from 8 to 17.6%, with variability attributed to ethnic background, the number of genes tested, cancer phenotypes, and patient...

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Identifiers

PMID: 40779059
DOI: 10.1007/s10689-025-00489-1
PMCID: PMC12334452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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