Article
Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression.
The Journal of clinical investigation - 3 Nov 2025
Kramer Michael H, Richardson Stephanie N, Li Yang, Yin Tiankai, Helton Nichole M, George Daniel R, Cai Michelle, Ramakrishnan Sai Mukund, Katerndahl Casey Ds, Miller Christopher A, Ley Timothy J
Abstract excerpt
Mutations that initiate acute myeloid leukemia (AML) can cause clonal expansion without transformation (clonal hematopoiesis). Cooperating mutations, usually in signaling genes, are needed to cause overt disease, but these may require a specific fitness state to be tolerated. Here, we show that nearly all AMLs arising in a mouse model expressing 2 common AML-initiating mutations (Dnmt3aR878H and Npm1cA) acquired...
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