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Effects of DNA methylation and polygenic scores on self-reported suicidal ideation in psychoses: no evidence of epigenetic basis of polygenic risk.

Psychiatric genetics - 1 Oct 2025

Nader George, Ducharme Matisse, Gerretsen Philip, Fischer Corinne, Graff Ariel, De Luca Vincenzo

Abstract excerpt

INTRODUCTION: Schizophrenia is a significant clinical problem. Unfortunately, there are currently no biomarkers available for accurately identifying patients with schizophrenia who may be vulnerable to suicide. Because genetic and environmental factors play a role in suicide, we attempted to determine the role of DNA methylation and polygenic risk scores in the relationship to suicidal ideation. METHODS: Using a...

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PMID: 40762416
DOI: 10.1097/YPG.0000000000000398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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