Article
Effects of DNA methylation and polygenic scores on self-reported suicidal ideation in psychoses: no evidence of epigenetic basis of polygenic risk.
Psychiatric genetics - 1 Oct 2025
Nader George, Ducharme Matisse, Gerretsen Philip, Fischer Corinne, Graff Ariel, De Luca Vincenzo
Abstract excerpt
INTRODUCTION: Schizophrenia is a significant clinical problem. Unfortunately, there are currently no biomarkers available for accurately identifying patients with schizophrenia who may be vulnerable to suicide. Because genetic and environmental factors play a role in suicide, we attempted to dete...
Topics
- Humans
- DNA Methylation
- Suicidal Ideation
- Male
- Female
- Multifactorial Inheritance
- Adult
- Schizophrenia
- Psychotic Disorders
- Cross-Sectional Studies
- Epigenesis, Genetic
- Middle Aged
- Self Report
- Genetic Predisposition to Disease
- Risk Factors
- Genome-Wide Association Study
- Pilot Projects