Article
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2014
Mullins Niamh, Perroud Nader, Uher Rudolf, Butler Amy W, Cohen-Woods Sarah, Rivera Margarita, Malki Karim, Euesden Jack, Power Robert A, Tansey Katherine E, Jones Lisa, Jones Ian, Craddock Nick, Owen Michael J, Korszun Ania, Gill Michael, Mors Ole, Preisig Martin, Maier Wolfgang, Rietschel Marcella, Rice John P, Müller-Myhsok Bertram, Binder Elisabeth B, Lucae Susanne, Ising Marcus, Craig Ian W, Farmer Anne E, McGuffin Peter, Breen Gerome, Lewis Cathryn M
Abstract excerpt
Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome-wide association studies (GWAS) on suicide attempt (SA) and ideation have failed to identify specific genetic variants. Here, we conduct further GWAS and for the first time, use polygenic score analysis in cohorts of patients with mood disorders, to test for common genetic...
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