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Article

Genetic Overlap Between DSM-IV Major Depressive Disorder and Suicidal Behaviors: Evidence from Polygenic Risk Scores in Young Adult Twins.

Behavior genetics - 1 Nov 2025

Gillespie Nathan A, Su Mei-Hsin, Lannoy Séverine, Stephenson Mallory, Rentería Miguel E, Ceja Zuriel, Hickie Ian B, Martin Nicholas G, Edwards Alexis C

Abstract excerpt

Suicidal thoughts and behaviors (STBs) represent a significant public health concern. This study aimed to examine the extent to which polygenic risk scores (PRSs) for suicide attempt and major depression (MD) explain variance in suicidal ideation, plans, and attempts among young adult twins. Data from 2876 participants of European ancestry in the Brisbane Longitudinal Twin Study were analyzed. PRSs for MD and...

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Identifiers

PMID: 40991153
DOI: 10.1007/s10519-025-10234-0
PMCID: PMC12719343

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