Article
Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes.
PloS one - 1 Jan 2012
Gelfand Jeffrey M, Goodin Douglas S, Boscardin W John, Nolan Rachel, Cuneo Ami, Green Ari J
Abstract excerpt
BACKGROUND: To determine whether retinal axonal loss is detectable in patients with a clinically isolated syndrome (CIS), a first clinical demyelinating attack suggestive of multiple sclerosis (MS), and examine patterns of retinal axonal loss across MS disease subtypes. METHODOLOGY/PRINCIPAL FINDINGS: Spectral-domain Optical Coherence Tomography was performed in 541 patients with MS, including 45 with high-risk...
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