Article

Application of an Integrated Single-Cell and Three-Dimensional Spheroid Culture Platform in Investigating Drug Resistance Heterogeneity and EMT in Lung Cancer Subclones

2024-12-25

Abstract excerpt

Lung cancer is a leading cause of cancer-related mortality worldwide, largely due to its heterogeneity and intrinsic drug resistance. Malignant pleural effusions (MPE) provide diverse tumor cell populations ideal for studying these complexities. Although chemotherapy and tar-geted therapies can be initially effective, subpopulations of cancer cells with phenotypic plasticity often survive treatment, eventually dev...

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Literature Corpus work: 87a21239-5dc7-571e-96c0-d22a9a75ef6d
DOI: 10.20944/preprints202412.2142.v1

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