Article
CHRNA3 genetic polymorphism and the risk of lung cancer in the Chinese Han smoking population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2015
Zhou Wenjing, Geng Tingting, Wang Huijuan, Xun Xiaojie, Feng Tian, Zou Hui, Kang Longli, Jin Tianbo, Chen Chao
Abstract excerpt
Lung cancer is the leading cause of cancer-related deaths worldwide that result from the combined effected of smoking exposure and genetic susceptibility. CHRNA3, a nicotinic acetylcholine receptor gene, was associated with lung cancer risk. The aim of this study was to identify whether CHRNA3 polymorphisms increase lung cancer risk directly or indirectly through smoking behavior in the Chinese Han individuals....
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