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Article

Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.

Nature communications - 2 Aug 2025

Lv Guohua, Sayles Nicole M, Huang Yun, Mancinelli Chiara, McAvoy Kevin, Shneider Neil A, Manfredi Giovanni, Kawamata Hibiki, Eliezer David

Abstract excerpt

Mitochondrial proteins CHCHD10 and CHCHD2 are mutated in rare cases of heritable FTD, ALS and PD and aggregate in tissues affected by these diseases. Here, we show that both proteins form amyloid fibrils and report cryo-EM structures of fibrils formed from their disordered N-terminal domains. The ordered cores of these fibrils are comprised of a region highly conserved between the two proteins, and a subset of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40753073
DOI: 10.1038/s41467-025-62149-3
PMCID: PMC12318133

Genes

CHCHD10
CHCHD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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