Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses

Abstract excerpt

ABSTRACT Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes that arise under these conditions and their contribution to drug tolerance are poorly understood. A pharmacodynamic marker called the RS ratio ® quantifies...

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