Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating fatty liver disease-associated adverse outcome pathways of perfluorooctane sulfonate using a systems toxicology approach.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jun 2023

Kim Moosoo, Kim Sang Heon, Choi Jun Yeong, Park Yong Joo

Abstract excerpt

Adverse outcome pathway (AOP) frameworks help elucidate toxic mechanisms and support chemical regulation. AOPs link a molecular initiating event (MIE), key events (KEs), and an adverse outcome by key event relationships (KERs), which assess the biological plausibility, essentiality, and empirical evidence involved. Perfluorooctane sulfonate (PFOS), a hazardous poly-fluoroalkyl substance, demonstrates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Factual
Share to Non-alcoholic Fatty Liver Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Risk Assessment

Source

Identifiers

PMID: 37059384
DOI: 10.1016/j.fct.2023.113781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating fatty liver disease-associated adverse outcome pathways of perfluorooctane sulfonate using a systems toxicology approach.PMID 37059384Read ↗

Mining Public Toxicogenomic Data Reveals Insights and Challenges in Delineating Liver Steatosis Adverse Outcome PathwaysSemantic proximity Read ↗

PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver DiseaseSemantic proximity Read ↗

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized MiceSemantic proximity Read ↗

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterizationSemantic proximity Read ↗

Investigating the mode of action for liver toxicity and wasting-like responses produced by high dose exposures to longer chain perfluoroacid substances (PFAS) using high throughput transcriptomicsSemantic proximity Read ↗

Chronic exposure to PFAS triggers systems-level cellular reprogramming independent of their bioaccumulationSemantic proximity Read ↗

Integrative omics analyses uncover the mechanism underlying the immunotoxicity of perfluorooctanesulfonate in human lymphocytesSemantic proximity Read ↗

Integrating high-throughput phenotypic profiling and transcriptomic analyses to predict the hepatosteatosis effects induced by per- and polyfluoroalkyl substances.Semantic proximity Read ↗

Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factorsSemantic proximity Read ↗

PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth—a translational research frameworkSemantic proximity Read ↗

Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 miceSemantic proximity Read ↗

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.