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Article

Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors

1 Jan 2022

Abstract excerpt

Abstract Perfluorooctane sulfonate (PFOS) is a widespread persistent environmental pollutant implicated in nephrotoxicity with altered metabolism, carcinogenesis, and fibrosis potential. We studied the underlying epigenetic mechanism involving transcription factors of PFOS-induced kidney injury. A 14-day orally dosed mouse model was chosen to study acute influences in vivo. Messenger RNA expression analysis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35633893
DOI: 10.1093/eep/dvac010

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