Back to search

Article

Chronic Kidney Disease: A Benefit-Risk Panorama of Baricitinib through Integrating Network Toxicology, Molecular Docking and Real-World Evidence

2025-09-10

Abstract excerpt

<title>Abstract</title> <p>Background Chronic kidney disease (CKD) poses substantial global morbidity and mortality burdens, yet current therapeutic strategies fail to halt or reverse renal fibrosis. Baricitinib, a selective JAK1/JAK2 inhibitor, demonstrates dual anti-inflammatory and anti-fibrotic properties in autoimmune conditions; however, its comprehensive therapeutic utility and safety constraints in CKD re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d4429360-7dd8-528f-94a7-4bfe72fe0c47
DOI
10.21203/rs.3.rs-7498649/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Chronic Kidney Disease: A Benefit-Risk Panorama of Baricitinib through Integrating Network Toxicology, Molecular Docking and Real-World EvidenceDOI 10.21203/rs.3.rs-7498649/v1
Network-based transcriptomic analysis identifies the genetic effect of COVID-19 to chronic kidney disease patients: A bioinformatics approachSemantic proximity
Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validationSemantic proximity
Characterizing hub biomarkers for post-transplant renal fibrosis and unveiling their immunological functions through RNA sequencing and advanced machine learning techniquesSemantic proximity
p53 as a Convergent Genetic Modifier in Chronic Kidney Disease: Unifying Genetic Risk and Defining Renal Modulatory DrugsSemantic proximity
Identification of common molecular signatures of SARS-CoV-2 infection and its influence on acute kidney injury and chronic kidney diseaseSemantic proximity
Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysisSemantic proximity
Evaluating the kidney disease progression using a comprehensive patient profiling algorithm: A hybrid clustering approachSemantic proximity
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19Semantic proximity
Multi-Omic Analysis Reveals Genetic Determinants and Therapeutic Targets of Chronic Kidney Disease and Kidney Function.Semantic proximity
Combining Network Toxicology with Machine Learning and Experiment Validation to Analyze the Molecular Mechanism and Core Target Screening of Aristolochic Acid NephropathySemantic proximity
Establishment of a integrative multi-omics expression database CKDdb in the context of chronic kidney disease (CKD)Semantic proximity
Real-World Safety Profile of Baricitinib and the Structural Basis of Viral Reactivation: A Multi-Disciplinary AnalysisSemantic proximity
Select a neighboring publication to make it the new centre.