Single-nucleotide polymorphisms in DNA repair genes ERCC, XRCC, and MGMT and implications in glioblastoma: a pathway analysis and structural dynamics study.

Abstract excerpt

Genes partaking in DNA damage repair (DDR) pathways exert a key role in the progression of glioblastoma (GBM) and treatment resistance. Essential DDR genes, including XRCC, ERCC, and MGMT, are mutated in GBM, with single nucleotide variants (SNVs) clinically linked to the. However, the structural consequences and biophysical alterations to protein dynamics linked to RCC/MGMT SNVs in GBM are not well-studied. We...

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• DNA Modification Methylases
• DNA Repair
• DNA Repair Enzymes
• Glioblastoma
• Hydrogen Bonding