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Article

Variations in gene and protein expression in canine chondrodystrophic nucleus pulposus cells following long-term three-dimensional culture.

PloS one - 1 Jan 2013

Iwata Munetaka, Ochi Hiroki, Asou Yoshinori, Haro Hirotaka, Aikawa Takeshi, Harada Yasuji, Nezu Yoshinori, Yogo Takuya, Tagawa Masahiro, Hara Yasushi

Abstract excerpt

Intervertebral disc (IVD) degeneration greatly affects quality of life. The nucleus pulposus (NP) of chondrodystrophic dog breeds (CDBs) is similar to the human NP, because the cells disappear with age and are replaced by fibrochondrocyte-like cells. However, because IVD develops as early as within the first year of life, we used canines as a model to investigate in vitro the mechanisms underlying IVD...

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Source

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Identifiers

PMID: 23658803
DOI: 10.1371/journal.pone.0063120
PMCID: PMC3642067

Genes

IVD
COMP
MMP13
MMP3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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