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Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair

14 Jun 2022

Abstract excerpt

A growing body of evidence in humans and animal models indicates an association between intervertebral disc degeneration (IDD) and increased fibrotic elements in the nucleus pulposus (NP). These include enhanced matrix turnover along with the abnormal deposition of collagens and other fibrous matrices, the emergence of fibrosis effector cells, such as macrophages and active fibroblasts, and the upregulation of...

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PMID: 35743056
DOI: 10.3390/ijms23126612

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