Article

Mutational burden of hepatoblastomas: a role for the <i>CX3CL1/CX3CR1</i> chemokine signaling pathway

2019-02-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hepatoblastoma is an embryonal liver tumor supposed to arise from the impairment of hepatocyte differentiation during embryogenesis. CTNNB1 is the only recurrently mutated gene, and this relative paucity of somatic mutations poses a challenge to risk stratification and development of targeted therapies. <h4>Methods</h4> In this study, we investigated by exome sequencing the...

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Literature Corpus work: c2131e6c-2ad2-53de-9de7-89804fcbb434
DOI: 10.1101/555466

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