Article

A quantitative universal NGS-based ctDNA assay for hepatoblastoma

2022-09-21

Abstract excerpt

Driver mutations in CTNNB1 are a hallmark of hepatoblastoma and offer a common biomarker for a liquid biopsy approach based on the presence of CTNNB1 circulating tumor DNA (ctDNA). We developed and investigated the utility of a quantitative universal next-generation sequencing (NGS) ctDNA assay for hepatoblastoma (QUENCH) to detect CTNNB1 ctDNA and assessed the links between ctDNA and current clinical indicators/b...

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Literature Corpus work: a248ff9b-79a2-5e17-8744-47aaec560dfb
DOI: 10.1101/2022.09.20.22279947

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