Article

ZEB1 Directly Inhibits GPX4 Transcription Contributing to ROS Accumulation in Breast Cancer Cells

2021-04-26

Abstract excerpt

<title>Abstract</title> <p>Prior studies have noted that Zinc finger E-box binding homeobox 1 (ZEB1) is a master transcription regulator, affecting the expression of nearly 2,000 genes in breast cancer cells, especially in epithelial-mesenchymal transition (EMT) process. In this study, we found that ZEB1 directly regulated Glutathione peroxidase 4 (GPX4) transcriptions, which was closely related to tumor reactive...

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Literature Corpus work: 4d750762-0b60-5f6a-9f3a-0d47924d1403
DOI: 10.21203/rs.3.rs-416905/v1

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