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Single‐cell RNA‐seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63

26 Oct 2018

Abstract excerpt

Cancers acquire resistance to systemic treatment with platinum-based chemotherapy (eg, cisplatin [CDDP]) as a result of a dynamic intratumoral heterogeneity (ITH) and clonal repopulation. However, little is known about the influence of chemotherapy on ITH at the single-cell level. Here, mapping the transcriptome of cancers treated with CDDP by scRNA-seq, we uncovered a novel gene, COX7B, associated with...

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PMID: 30367559
DOI: 10.1002/cam4.1828

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